Great news, there is a new Electronic Lab Notebook (ELN) out on the market, and is originates in part from the makers of the excellent Papers App.
Its still very much beta software, but the roadmap looks promising. Based on my limited testing so far the program seems very easy to use, an not as overly complicated as some of the other ELN out there, which I have often found overkill for my personal needs, and consequently too expensive. The bit I like the most is that the software does not depend on a server, and thus if the developers go bust, you still have the software, and your ELN. Perhaps the best bit so far is the price which is only $29 AUD, very reasonable, and thankfully no ongoing yearly subscription fees.
Looking forward to trying this out more over the next 6 months.
There has been a bit of press lately suggesting that Antioxidants might actually be bad for cancer… not good as they are commonly promoted in the media.
IFLS has put together a great article on some of the reasons why antioxidants might not be such a great thing [Link].
In addition, we recently wrote a review article about how different ‘stresses’ including oxidation can affect mitosis, and cancer. We also came to a similar conclusion in our review, that antioxidants were a complicated and not always benifical for treating cancer. One of the main reason we suggested this was due to the fact that many common antioxidants are part of the Flavonoid family. On the surface that sound great, but many Flavonoids also happen to potently inhibit cyclin dependent kinases (Cdks). Coincidentally, our other recent article in Cell Cycle, showed that partial inhibition of Cdk1 can dramatically disrupt mitosis and drive severe cytokinesis defects and polyploidy (see video below). These mitotic defects are the foundation of chromosome instability (CIN), which is a hallmark of more aggressive cancer types, that are also resistant to most chemotherapies and treatments. In simple terms, there is a possibility that in some cases, taking large quantities of dietary Flavonoids (e.g red wine, dark chocolate etc) could drive the formation of more aggressive cancers. This is definitely an area that needs a lot more research, and as always make sure that you fully discuss any dietary and supplements with your oncologist.
This is what happens when a ‘fairly normal’ cancer cell is treated with low doses of a Cdk1 inhibitor.
Here is a picture of a polyploid cancer cell, which was produced by partially inhibiting Cdk1.
Great News…. As a part of National Science Week here in Australia, Cell Division Lab will be co-representing the Garvan Institute at a very special event hosted by ScienceAlert “Space Oddity: A Special Science Week Event With Chris Hadfield“
Take your protein pills and put your helmet on and join astronaut Chris Hadfield in celebrating National Science Week. The former commander of the International Space Station became the coolest astronaut in the world when he recorded David Bowie’s “Space Oddity” in zero gravity. Since returning to Earth, the Canadian astronaut has inspired audiences across Europe and North America with live talks on space, science and achieving your dreams.
Now he’s heading to Australia for the first time, and in his only Sydney shows he’ll be appearing alongside social media celebrities Derek Muller (Veritasium), Dr Carin Bondar (Scientific American, Discovery) and Destin Sandlin (Smarter Every Day).
The live events will feature a blend of science talk, inspiring stories and performances. If you’re not already fascinated by science, you will be by the end of it.
There are still tickets available for the Adult show starting at 8pm. But you better be quick because the all ages show sold out in less than 10 hours.
You can buy your tickets here
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Great post and great blog on all things relating to fluorescent microscopy.
Originally posted on greenfluorescentblog:
In most microscopy images that are published in research papers, there appears a scale bar. The scale bar is like a ruler that allows you to compare sizes and distances in images from different sources. Although a scale bar is helpful for assessing by eye, many image processing programs allows you to measure distances in the image. The problem is that these measurements are in pixels. That is what I encountered when I wanted to measure certain objects in my images. How to convert from pixels to nanometers (or microns) requires a simple formula and some prior data as follows:
- Objective magnification
- Lens magnification (in some microscopes, it is possible to get extra mag of 1.25x, 1.6x or 2x.
- C mount (is usually 1x)
- Pixel size – is the actual pixel size of the camera that is attached to the microscope.
- Binning - i.e. combining a cluster of pixels to a…
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