We will be at the Sydney Light Optical Users Meeting on July 24th 2014

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Great news, Cell Division Lab will be at the  Sydney Light Optical Users Meeting, hosted by Dr Pamela Young at Sydney University, this Thursday (24th of July).

I will be presenting a short seminar on “Imaging and Analysing Cell Division”.

If you would like to attend please contact Pamela asap. Her details are below!

Hope to see you there !

Sydney Light Optical Users Meeting July 2014

Findings: A new, cheap, & very promising Electronic Lab Notebook

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Findings App

 

Great news, there is a new Electronic Lab Notebook (ELN) out on the market, and is originates in part from the makers of the excellent Papers App.

Its still very much beta software, but the roadmap looks promising. Based on my limited testing so far the program seems very easy to use, an not as overly complicated as some of the other ELN out there, which I have often found overkill for my personal needs, and consequently too expensive. The bit I like the most is that the software does not depend on a server, and thus if the developers go bust, you still have the software, and your ELN. Perhaps the best bit so far is the price which is only $29 AUD, very reasonable, and thankfully no ongoing yearly subscription fees.

Looking forward to trying this out more over the next 6 months.

Anti-Oxaidants and Cancer…A complicated story!

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There has been a bit of press lately suggesting that Antioxidants might actually be bad for cancer… not good as they are commonly promoted in the media.
IFLS has put together a great article on some of the reasons why antioxidants might not be such a great thing [Link].

In addition, we recently wrote a review article about how different ‘stresses’ including oxidation can affect mitosis, and cancer. We also came to a similar conclusion in our review,  that antioxidants were a complicated and not always benifical for treating cancer. One of the main reason we suggested this was due to the fact that many common antioxidants are part of the Flavonoid family. On the surface that sound great, but many Flavonoids also happen to potently inhibit cyclin dependent kinases (Cdks). Coincidentally, our other recent article in Cell Cycle, showed that partial inhibition of Cdk1 can dramatically disrupt mitosis and drive severe cytokinesis defects and polyploidy (see video below). These mitotic defects are the foundation of chromosome instability  (CIN), which is a hallmark of more aggressive cancer types, that are also resistant to most chemotherapies and treatments. In simple terms, there is a possibility that in some cases, taking large quantities of dietary Flavonoids (e.g red wine, dark chocolate etc) could drive the formation of more aggressive cancers. This is definitely an area that needs a lot more research, and as always make sure that you fully discuss any dietary and supplements with your oncologist.

 

This is what happens when a ‘fairly normal’ cancer cell is treated with low doses of a Cdk1 inhibitor.

Here is a picture of a polyploid cancer cell, which was produced by partially inhibiting Cdk1.

ImageJ=1.48f unit=micron

 

Were Presenting at “Space Oddity: A Special Science Week Event With Chris Hadfield”

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Great News…. As a part of  National Science Week here in Australia, Cell Division Lab will be co-representing the Garvan Institute at a very special event hosted by ScienceAlert  “Space Oddity: A Special Science Week Event With Chris Hadfield

Take your protein pills and put your helmet on and join astronaut Chris Hadfield in celebrating National Science Week. The former commander of the International Space Station became the coolest astronaut in the world when he recorded David Bowie’s “Space Oddity” in zero gravity. Since returning to Earth, the Canadian astronaut has inspired audiences across Europe and North America with live talks on space, science and achieving your dreams.

Now he’s heading to Australia for the first time, and in his only Sydney shows he’ll be appearing alongside social media celebrities Derek Muller (Veritasium), Dr Carin Bondar (Scientific American, Discovery) and Destin Sandlin (Smarter Every Day).

The live events will feature a blend of science talk, inspiring stories and performances. If you’re not already fascinated by science, you will be by the end of it.

There are still tickets available for the Adult show starting at 8pm. But you better be quick because the all ages show sold out in less than 10 hours.

You can buy your tickets here

 

 

Calculating the pixel sizes on images

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celldivisionlab:

Great post and great blog on all things relating to fluorescent microscopy.

Originally posted on greenfluorescentblog:

In most microscopy images that are published in research papers, there appears a scale bar.  The scale bar is like a ruler that allows you to compare sizes and distances in images from different sources.  Although a scale bar is helpful for assessing by eye, many image processing programs allows you to measure distances in the image. The problem is that these measurements are in pixels. That is what I encountered when I wanted to measure certain objects in my images. How to convert from pixels to nanometers (or microns) requires a simple formula and some prior data as follows:

  1. Objective magnification
  2. Lens magnification (in some microscopes, it is possible to get extra mag of 1.25x, 1.6x or 2x.
  3. C mount (is usually 1x)
  4. Pixel size – is the actual pixel size of the camera that is attached to the microscope.
  5. Binning – i.e. combining a cluster of pixels to a…

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Our Latest Review Article “Stressing Mitosis to Death” is now online !

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Great news, our latest review article “Stressing Mitosis to Death” has been accepted for publication by Frontiers in Oncology. You can access the provisional pre-press version here.

The review is about how common stresses affect mitosis, and the impact these stresses can have on the blockbuster mitotic chemotherapy drug Taxol (paclitaxel)

Finally here is one of the beautiful figures drawn by our own Sam Rogers for the Review!  Hope you enjoy the read !

 

Fig. v4

Were the front cover feature image on this months issue of Cell Cycle !

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Some more good news to coincide with today’s official release of our manuscript, one of our images has been chosen to be the feature image on the front cover.

It’s a great honour, one that I am very proud of, and is the first time I have ever had a front cover !
You can view the current issue (Volume 13 – Issue 9 – May 1, 2014) here.

Or jump directly to our paper here

Front Cover 

FrontCoverCC13-9

 

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3 New Amazing Biomedical Animations by VIZBIplus !

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In a follow-up to the post I made a week or so ago on the amazing “Cancer is not one disease video“, there are now an additional 2 stunning videos from the very talented people from VIZBIplus covering the The Hungry Microbiome and Inflammation & Type 2 Diabetes.

The clips are a labour of love and have been a year in the making. To celebrate their birth, the red carpet will literally be rolled out for their creators, three scientist-animators: Dr Kate Patterson from Garvan, Chris Hammang from CSIRO, and Dr Maja Divjak from Melbourne’s Walter and Eliza Hall Institute of Medical Research.[Link]

 

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Cell Division Lab is now on Flickr !

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We now have a Flickr page where we will be uploading and storing all of our images.

You can find us here and feel free to share our pics!

Flickr Page

 

The VizbiPlus Challenge: Call for Entries

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Want to win a very cool Wacom Cintiq 13HD!

Got some amazing Science Artwork you want to show off?

Then why not enter the VizbiPlus Challenge !

‘VizbiPlus: Visualising the Future of Biomedicine’ is a new project funded by the Inspiring Australia government initiative, the Garvan Institute of Medical Research, the Walter & Eliza Hall Institute, and CSIRO. Its goal is to train three scientists to create scientifically accurate 3D animations that explain the latest biomedical research in a way that inspires and engages the general public, and then present this work in public events to maximise the reach of the work.