Month: November 2013

Cell Brains – Image of the Week

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Here is a HeLa cell in the first stages of mitosis (prophase) just as it has begun to condensing its DNA into chromosomes. At this point it looks strikingly similar to the folds of a human brain. The image has been put through a few photoshop filters to give this stunning final image.Cell-Brains-Colour-web

Our New Name is the “Cell Division Lab”

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After some deep thought and consultation with my lab, I have decided to change the lab name from the Mitotic Control lab to the more flexible and public friendly “Cell Division” lab. We feel this name is much simpler to understand, especially for those that are not specialist in the field. It also provides more flexibility for our future research goals, which may take us beyond the control mechanisms that govern mitosis.
All the best

Andrew Burgess
Head of the Cell Division Lab

Persin Paper on reversal of Tamoxifen resistance Now Online !

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Rachael’s Paper is now on-line  [Link]

Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells

“The cytotoxic effects of persin are CASP-4 dependent and mediated by CHOP-dependent and -independent ERS signalling cascades. Increased ERS signalling contributes to persin-induced reversal of tamoxifen resistance.”

In simple terms, Persin a toxin from avocados, helps reverse tamoxifen resistance in breast cancer cell lines. Tamoxifen is a critical front line chemotherapeutic drug which has been instrumental in improving the survival rates for women with breast cancer. Future trials are needed to confirm that this result translates to the to humans and then the clinic, but never the less it is still an exciting finding, and a proof of principal that tamoxifen resistance can be reversed.