Rachael’s Paper is now on-line [Link]
Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells
“The cytotoxic effects of persin are CASP-4 dependent and mediated by CHOP-dependent and -independent ERS signalling cascades. Increased ERS signalling contributes to persin-induced reversal of tamoxifen resistance.”
In simple terms, Persin a toxin from avocados, helps reverse tamoxifen resistance in breast cancer cell lines. Tamoxifen is a critical front line chemotherapeutic drug which has been instrumental in improving the survival rates for women with breast cancer. Future trials are needed to confirm that this result translates to the to humans and then the clinic, but never the less it is still an exciting finding, and a proof of principal that tamoxifen resistance can be reversed.