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Our Latest Publication Accepted and Now Online!

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Great news our latest publication “Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs” has been accepted by the top Proteomics Journal Molecular & Cellular Proteomics.

You can currently download the unformatted version for free here [link]

And here is an still image from the paper showing live HeLa cells undergoing forced phosphatase dependent mitotic exit. The red colour is Histone H2B tagged with the fluorescent mCherry protein, and the Green is tubulin tagged with GFP (green fluorescent protein).

 

HeLa cells undergoing phosphatase dependent mitotic exit
HeLa cells undergoing phosphatase dependent mitotic exit

 

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Public Talk “Killing Cancer One Cell at a Time ” now on YouTube

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Here is a recent talk I gave to some members of the public at the Garvan Institute of Medical Research.

It is a very general and simple over-view of explaining 1) how cells in your body proliferate, 2) how this goes wrong in cancer, 3) the challenges we are facing in treating and killing cancer, and 4) most importantly how we hoping to improve current treatments in the near future.

A big thanks to all the fantastic Garvan Foundation Team who hosted, filmed, and edited the event.

2014 Garvan Cancer Division PhD Open Day, 10th September !

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Are you interested in Cancer Research and want to do a PhD at the Garvan?
Then come along to the open day and where you can meet with all the supervisors, discover some amazing projects, and get all the information you need to start your career in Cancer Research.

Information

  • Date: Wednesday 10th of September 2014
  • Time: 1.45-5pm
  • Venue: The Kinghorn Cancer Centre, Garvan Institute of Medical Research, 370 Victoria St, Darlinghurst

Registration is free but limited to the first 25 registrants, and closes at 4.00 pm on Tuesday, 09th Sep 2014.

For more information and to register for the day, please visit the website [link] or contact Dr Alessandra Bray.

ImpactStory: A new way to track individual article metrics

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UPDATE: ImpactStory is not free, as I first thought, they currently have a 30 day free trail, then the cost is $45/year.

Its clear that judging a researchers output purely on the impact/quality of the journal they do/don’t publish is not always the best way to accurately judge individual achievement and output. To that end, article level metrics have recently emerged as a potential way to generate a more accurate picture of a individual researchers output.

I hadn’t really taken much notice of article metrics, however a friend at work recently told me about Impactstory, a new website that is….

an open-source, web-based tool that helps researchers explore and share the diverse impacts of all their research products—from traditional ones like journal articles, to emerging products like blog posts, datasets, and software

Its very quick and easy to signup and quickly get a snapshot of your article specific metrics. You can see my results here [link].

Interestingly, my PlosOne paper is ranked 3rd, above the 4th placed EMBO publication, which according to the traditional Impact Factor measurement would be viewed as a much, much, much better publication.

Impactstory

 

Another player in this space is ResearchGate, which has been around for much longer. It gives you a RG score, which “takes all your research and turns it into a source of reputation”.

How does the RG Score work?
Your RG Score is calculated based on how other researchers interact with your content, how often, and who they are. The higher their score, the more yours will increase.

Here is an example of what a profile looks like:

ResearchGate

 

 

Its going to be very interesting to see how these new metrics impact on the judging of individual scientists output, and if, when and which metric grant funding bodies will prefer.

We will be at the Sydney Light Optical Users Meeting on July 24th 2014

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Great news, Cell Division Lab will be at the  Sydney Light Optical Users Meeting, hosted by Dr Pamela Young at Sydney University, this Thursday (24th of July).

I will be presenting a short seminar on “Imaging and Analysing Cell Division”.

If you would like to attend please contact Pamela asap. Her details are below!

Hope to see you there !

Sydney Light Optical Users Meeting July 2014

Findings: A new, cheap, & very promising Electronic Lab Notebook

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Findings App

 

Great news, there is a new Electronic Lab Notebook (ELN) out on the market, and is originates in part from the makers of the excellent Papers App.

Its still very much beta software, but the roadmap looks promising. Based on my limited testing so far the program seems very easy to use, an not as overly complicated as some of the other ELN out there, which I have often found overkill for my personal needs, and consequently too expensive. The bit I like the most is that the software does not depend on a server, and thus if the developers go bust, you still have the software, and your ELN. Perhaps the best bit so far is the price which is only $29 AUD, very reasonable, and thankfully no ongoing yearly subscription fees.

Looking forward to trying this out more over the next 6 months.

Anti-Oxaidants and Cancer…A complicated story!

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There has been a bit of press lately suggesting that Antioxidants might actually be bad for cancer… not good as they are commonly promoted in the media.
IFLS has put together a great article on some of the reasons why antioxidants might not be such a great thing [Link].

In addition, we recently wrote a review article about how different ‘stresses’ including oxidation can affect mitosis, and cancer. We also came to a similar conclusion in our review,  that antioxidants were a complicated and not always benifical for treating cancer. One of the main reason we suggested this was due to the fact that many common antioxidants are part of the Flavonoid family. On the surface that sound great, but many Flavonoids also happen to potently inhibit cyclin dependent kinases (Cdks). Coincidentally, our other recent article in Cell Cycle, showed that partial inhibition of Cdk1 can dramatically disrupt mitosis and drive severe cytokinesis defects and polyploidy (see video below). These mitotic defects are the foundation of chromosome instability  (CIN), which is a hallmark of more aggressive cancer types, that are also resistant to most chemotherapies and treatments. In simple terms, there is a possibility that in some cases, taking large quantities of dietary Flavonoids (e.g red wine, dark chocolate etc) could drive the formation of more aggressive cancers. This is definitely an area that needs a lot more research, and as always make sure that you fully discuss any dietary and supplements with your oncologist.

 

This is what happens when a ‘fairly normal’ cancer cell is treated with low doses of a Cdk1 inhibitor.

Here is a picture of a polyploid cancer cell, which was produced by partially inhibiting Cdk1.

ImageJ=1.48f unit=micron

 

Our Latest Review Article “Stressing Mitosis to Death” is now online !

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Great news, our latest review article “Stressing Mitosis to Death” has been accepted for publication by Frontiers in Oncology. You can access the provisional pre-press version here.

The review is about how common stresses affect mitosis, and the impact these stresses can have on the blockbuster mitotic chemotherapy drug Taxol (paclitaxel)

Finally here is one of the beautiful figures drawn by our own Sam Rogers for the Review!  Hope you enjoy the read !

 

Fig. v4

3 New Amazing Biomedical Animations by VIZBIplus !

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In a follow-up to the post I made a week or so ago on the amazing “Cancer is not one disease video“, there are now an additional 2 stunning videos from the very talented people from VIZBIplus covering the The Hungry Microbiome and Inflammation & Type 2 Diabetes.

The clips are a labour of love and have been a year in the making. To celebrate their birth, the red carpet will literally be rolled out for their creators, three scientist-animators: Dr Kate Patterson from Garvan, Chris Hammang from CSIRO, and Dr Maja Divjak from Melbourne’s Walter and Eliza Hall Institute of Medical Research.[Link]

 

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The VizbiPlus Challenge: Call for Entries

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Want to win a very cool Wacom Cintiq 13HD!

Got some amazing Science Artwork you want to show off?

Then why not enter the VizbiPlus Challenge !

‘VizbiPlus: Visualising the Future of Biomedicine’ is a new project funded by the Inspiring Australia government initiative, the Garvan Institute of Medical Research, the Walter & Eliza Hall Institute, and CSIRO. Its goal is to train three scientists to create scientifically accurate 3D animations that explain the latest biomedical research in a way that inspires and engages the general public, and then present this work in public events to maximise the reach of the work.