Selected Recent Publications

  1. Rajal, A.G., Marzec, K.A., McCloy, R.A., Nobis, M., Chin, V., Hastings, J.F., Lai, K., Kennerson, M., Hughes, W.E., Vaghjiani, V., Timpson, P., Cain, J.E., Watkins, D.N., Croucher, D.R., Burgess, A., 2021. A non-genetic, cell cycle dependent mechanism of platinum resistance in lung adenocarcinoma. Elife 10, e65234.
  2. Cochrane, C.R., Vaghjiani, V., Szczepny, A., Jayasekara, W.S.N., Gonzalez-Rajal, A., Kikuchi, K., McCaughan, G.W., Burgess, A., Gough, D.J., Watkins, D.N., Cain, J.E., 2020. Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling. The Journal of Clinical Investigation 130.
  3. Lee, C., Fernandez, K.J., Alexandrou, S., Sergio, C.M., Deng, N., Rogers, S., Burgess, A., Caldon, C.E., 2020. Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer. Cancers 12, 2268.
  4. Burgess, A., Caldon, C.E., 2020. Editorial: Proceedings From ACCM19: Cell Cycle, DNA Damage Response and Telomeres. Frontiers Cell Dev Biology 8, 805.
  5. Sinha, D., Nag, P., Nanayakkara, D., Duijf, P.H.G., Burgess, A., Raninga, P., Smits, V.A.J., Bain, A.L., Subramanian, G., Wall, M., Finnie, John.W., Kalimutho, M., Khanna, K.K., 2020. Cep55 overexpression promotes genomic instability and tumorigenesis in mice. Commun Biology 3, 593.
  6. Johnson, T.G., Schelch, K., Lai, K., Marzec, K.A., Kennerson, M., Grusch, M., Reid, G., Burgess, A., 2020. YB-1 Knockdown Inhibits the Proliferation of Mesothelioma Cells through Multiple Mechanisms. Cancers 12, 2285.
  7. Gonzalez-Rajal, A., Hastings, J.F., Watkins, D.N., Croucher, D.R., Burgess, A., 2020. Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma. Frontiers Cell Dev Biology 8, 305.
  8. Hastings, J.F., Rajal, A.G., Latham, S.L., Han, J.Z., McCloy, R.A., O’Donnell, Y.E., Phimmachanh, M., Murphy, A.D., Nagrial, A., Daneshvar, D., Chin, V., Watkins, D.N., Burgess, A., Croucher, D.R., 2020. Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma. Elife 9, e53367.
  9. Hunt, N.J., Lockwood, G.P., Couteur, F.H.L., McCourt, P.A.G., Singla, N., Kang, S.W.S., Burgess, A., Kuncic, Z., Couteur, D.G.L., Cogger, V.C., 2020. Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots. Acs Nano 14, 1492–1507.
  10. Burgess, A., Vuong, J., Marzec, K., Lichtenberg, U., O’Donoghue, S., Jensen, L. (2019). SnapShot: S-Phase Entry and Exit Cell 179(3), 802-802.e1.
  11. Burgess, A., Vuong, J., Marzec, K., Lichtenberg, U., O’Donoghue, S., Jensen, L. (2019). A Compendium to S-Phase Entry and Exit Zenodo
  12. Laan, S., Lévêque, M., Marcellin, G., Vezenkov, L., Lannay, Y., Dubra, G., Bompard, G., Ovejero, S., Urbach, S., Burgess, A., Amblard, M., Sterkers, Y., Bastien, P., Rogowski, K. (2019). Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination Cell Reports 29(12), 4159-4171.e6.
  13. Burgess, A., Vuong, J., Rogers, S., Marzec, K., Malumbres, M., O’Donoghue, S. (2019). A Compendium to the Phosphoregulation of Mitosis Zenodo
  14. Pavey, S., Pinder, A., Fernando, W., D’Arcy, N., Matigian, N., Skalamera, D., Cao, K., Loo‐Oey, D., Hill, M., Stark, M., Kimlin, M., Burgess, A., Cloonan, N., Sturm, R., Gabrielli, B. (2019). Multiple interaction nodes define the post‐replication repair response to UV‐induced DNA damage that is defective in melanomas and correlated with UV signature mutation load Molecular Oncology
  15. Johnson, T., Schelch, K., Mehta, S., Burgess, A., Reid, G. (2019). Why Be One Protein When You Can Affect Many? The Multiple Roles of YB-1 in Lung Cancer and Mesothelioma Frontiers in Cell and Developmental Biology 7(), 221.
  16. Caldon, C., Burgess, A. (2019). Label Free, Quantitative Single-Cell Fate Tracking of Time-Lapse Movies MethodsX 6, 2468-2475.
  17. Marzec KA, Burgess A. Oncogenic functions of MASTL kinase. Front Cell Dev Biol (2018) 6: [Link]
  18. Shearer RF, Frikstad K-AM, McKenna J, McCloy RA, Deng N, Burgess A, Stokke T, Patzke S, Saunders DN. The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia. Mol Biol Cell (2018) 29:1542–1554. [Link]
  19. Marini KD, Croucher DR, McCloy RA, Vaghjiani V, Gonzalez-Rajal A, Hastings JF, Chin V, Szczepny A, Kostyrko K, Marquez C, et al…Burgess A…et al. (2018). Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. Sci Transl Med  10:eaat3504. [Link]
  20. Rogers, S., McCloy, R.A., Parker, B.L., Gallego-Ortega, D., Law, A.M.K., Chin, V.T., Conway, J.R.W., Fey, D., Millar, E.K.A., O’Toole, S., Deng, N., Swarbrick, A., Chastain, P.D., Cesare, A.J., Timpson, P., Caldon, C.E., Croucher, D.R., James, D.E., Watkins, D.N., Burgess, A., (2018). MASTL overexpression promotes chromosome instability and metastasis in breast cancer. Oncogene 432, 980. [Link]
  21. Szczepny A, Carey K, McKenzie L, Jayasekara S, Rossello F, Gonzalez-Rajal A, McCaw A, Popovski D, Wang D, Sadler A, Maher A, Russell P, Wright G, McCloy R, Garama D, Gough D, Baylin S, Burgess A, Cain J & Watkins DN (2018) The Tumor Suppressor Hic1 Maintains Chromosomal Stability Independent of Tp53. Oncogene 37, 14. [Link]
  22. Chou A, Froio D, Nagrial AM, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, et al (2018) Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer. Gut 67, 12 [Link]
  23. Law AMK, Yin JXM, Castillo L, Young AIJ, Piggin C, Rogers S, Caldon CE, Burgess A, et al (2017) Andy’s Algorithms: new automated digital image analysis pipelines for FIJI. Scientific Reports 7: 496 [Link]
  24. Burgess, A., Vuong, J., Rogers, S., Malumbres, M., and O’Donoghue, S. I. (2017) SnapShot: Phosphoregulation of Mitosis. Cell 169, 1358–1358.e1 [PDF Link][Interactive Website]
  25. Charrasse, S., Gharbi-Ayachi, A., Burgess, A., Vera, J., Hached, K., Raynaud, P., Schowb, E., Lorca, T., and Castro, A. (2017) Ensa controls S-phase length by modulating Treslin levels. Nat Commun, 8, 333. [Link]
  26. Szczepny, A., Rogers, S., Jayasekara, W. S. N., Park, K., McCloy, R. A., Cochrane, C. R., Ganju, V., Cooper, W. A., Sage, J., Peacock, C. D., Cain, J. E., *Burgess, A., and *Watkins, D. N. (2017) The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer. Oncogene 23 *co-corresponding author [Link]
  27. Vennin, C. et al…. Burgess, A., Cox, T. R., Morton, J. P., Pajic, M., and Timpson, P. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science translational medicine. 9, 384 . [Link][Feature Article]
  28. Haupt, S., Vijayakumaran, R., Panimaya, J., Burgess, A., Lim, E., and Haupt, Y. (2017). The role of MDM2 and MDM4 in breast cancer development and prevention. Journal of molecular cell biology. 9, 1, 53–61. [Link]
  29. Gabrielli, B.G. and Burgess, A. (2016). Cdc25 Family Phosphatases in Cancer. Protein Tyrosine Phosphatases in Cancer. B.G. Neel and N.K. Tonks, eds. Springer New York. 283–306. [Link]
  30. Rogers, S., Fey, D., McCloy, RA., Parker, BL., Mitchell, NJ., Payne, RJ., Daly, RJ., James, DE., Caldon, CE., Watkins, DN., Croucher, DR., Burgess, A. (2016) PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells. J Cell Sci 129 (7), 1340-1354. [Link][Feature Article]
  31. Burgess, A., Chia, KM., Haupt, S., Thomas, D., Haupt, Y., Lim, E. (2016) Clinical overview of MDM2/X targeted therapies Frontiers in Oncology 6, 7 [Link]
  32. Rogers, S., McCloy, R., Watkins, D. N. and Burgess, A. (2016). Mechanisms regulating phosphatase specificity and the removal of individual phosphorylation sites during mitotic exit. BioEssays.[Link]
  33. Rogers, S., McCloy, R. A., Parker, B. L., Chaudhuri, R., Gayevskiy, V., Hoffman, N. J., Watkins, D. N., Daly, R. J., James, D. E. and Burgess, A. (2015). Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells. Data in Brief 5, 45–52.[Link]
  34. McCloy, R., Parker, B. L., Rogers, S., Chaudhuri, R., Gayevskiy, V., Hoffman, N. J., Ali, N., Watkins, D. N., Daly, R., James, D. E., Lorca, T., Castro, A., and Burgess, A. (2015) Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs. Molecular & Cellular Proteomics. 14, 2194–2212 (I.F = 7.25) [LinkF1000Prime Recommended Front Cover 
  35. Burgess, A. (2015) Degrading Claspin away with Cdh1 and Cyclin A. Cell Cycle 14, 171–171 (I.F = 5.36) [Link].
  36. Rogers, S., Gloss, B. S., Lee, C. S., Sergio, C. M., Dinger, M. E., Musgrove, E. A., Burgess, A., and Caldon, C. E. (2015) Cyclin E2 is the predominant E-cyclin associated with NPAT in breast cancer cells. Cell Division 10, 1 (I.F = 2.63) [Link].
  37. McCloy RA, Rogers S, Caldon CE, Lorca T, Castro A, Burgess A. (2014) Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events. Cell Cycle.  2014 Mar 6;13(9):0–12. [Link] Front Cover
  38. McCloy RA, Shelley EJ, Roberts CG, Boslem E, Biden TJ, Nicholson RI, Gee JM, Sutherland RL, Musgrove EA, Burgess A, and Butt A (2013) Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells.
    Br. J. Cancer 109: 3034–3041 [Link]
  39. Burgess, A., Lorca, T., Castro, A (2012). Quantitative Live Imaging of Endogenous DNA Replication in Mammalian Cells. PLoS ONE. 7(9): e45726. [Link]
  40. Wigan, M., Pinder, A., Giles, N., Pavey, S., Burgess, A., Wong, S., Sturm, R. A., et al. (2012). A UVR-Induced G2-Phase Checkpoint Response to ssDNA Gaps Produced by Replication Fork Bypass of Unrepaired Lesions Is Defective in Melanoma. The Journal of Investigative Dermatology. 132(6):p1681-8 [Link]
  41. Vigneron S, Gharbi-Ayachi A, Raymond A, Burgess A, Labbé J, Labesse G, Monsarrat B, Lorca T & Castro A (2011) Characterization of the mechanisms controlling greatwall activity. Mol. Cell. Biol. 31(11): p.2262-2275 [Link]
  42. Gharbi-Ayachi, A., Labbé, JC., Burgess, A., Vigneron, S., Strub, JM., Brioudes, E., Van-Dorsselaer, A., Castro A and Lorca, T (2010). The Substrate of Greatwall kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase PP2A. Science (330) p.1673-1677 [LinkF1000Prime Recommendation
  43. Burgess, A., Brioudes, E., Vigneron, S., Labbe, JC., Lorca, T and Castro, A (2010) Human Greatwall controls mitotic entry and progression by maintaining a correct Cdc2/PP2A balance. PNAS. 107(28): p.12564-12569 [Link]
  44. Lorca, T., Bernis, C., Vigneron, S., Burgess, A., Brioudes, E., Labbe, JC and Castro, A (2010). Constant regulation of the MPF amplification loop and the Greatwall/PP2A pathway is required for a correct first Embronic cell division. J. Cell. Science. 123 (13): p.2281-2291. [Link]
  45. Vigneron, S., Brioudes, E., Burgess, A., Labbe, Jc., Lorca, T And Castro, A (2009) Greatwall maintains mitosis through regulation of PP2AEMBO Journal. 28(18): p. 2786-2793. [Link]
  46. Burgess, A., Labbe, Jc., Vigneron, S., Bonneaud, N., Strub, Van Dorsselaer, A., Lorca, T And Castro, A (2008) Chfr interacts and colocalizes with TCTP to the mitotic spindle.Oncogene27(42): p. 5554-5566. [Link]

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