Switching off Cancers Diversity

A defining feature in over 2/3rds of all solid tumours is the continual loss and gain of whole are small parts of chromosomes. This instability, or CIN for short, strongly implicated in tumour initiation, progression, chemoresistance and poor prognosis. CIN is created through failures during mitosis, whereby whole or parts of a chromosome are segregated […]

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New Paper Published : Quantitative Live Imaging of Endogenous DNA Replication in Mammalian Cells

I am pleased to announce that the latest publication for the lab is now available online at PLoS ONE [Link][PDF]. Below are some additional videos of the Chromotek HeLa cell line [link] undergoing cell division, with the Imaris Dot quantification overlaid, along with a instructional video on how to perform the dot quantification analysis using […]

Read More New Paper Published : Quantitative Live Imaging of Endogenous DNA Replication in Mammalian Cells