Great news, our latest article in @CellCycleJ is now online.
“Degrading Claspin away with Cdh1 and Cyclin A. Cell Cycle (2015)”
You can view the pre-print version here
The News and Views article is based on the recent publication by Oakes, V. et al. entitled “Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle” Cell Cycle 13, 3302–3311 (2014).
Here is a sneak peak at the figure from our article.
Here is a recent talk I gave to some members of the public at the Garvan Institute of Medical Research.
It is a very general and simple over-view of explaining 1) how cells in your body proliferate, 2) how this goes wrong in cancer, 3) the challenges we are facing in treating and killing cancer, and 4) most importantly how we hoping to improve current treatments in the near future.
A big thanks to all the fantastic Garvan Foundation Team who hosted, filmed, and edited the event.
There has been a bit of press lately suggesting that Antioxidants might actually be bad for cancer… not good as they are commonly promoted in the media.
IFLS has put together a great article on some of the reasons why antioxidants might not be such a great thing [Link].
In addition, we recently wrote a review article about how different ‘stresses’ including oxidation can affect mitosis, and cancer. We also came to a similar conclusion in our review, that antioxidants were a complicated and not always benifical for treating cancer. One of the main reason we suggested this was due to the fact that many common antioxidants are part of the Flavonoid family. On the surface that sound great, but many Flavonoids also happen to potently inhibit cyclin dependent kinases (Cdks). Coincidentally, our other recent article in Cell Cycle, showed that partial inhibition of Cdk1 can dramatically disrupt mitosis and drive severe cytokinesis defects and polyploidy (see video below). These mitotic defects are the foundation of chromosome instability (CIN), which is a hallmark of more aggressive cancer types, that are also resistant to most chemotherapies and treatments. In simple terms, there is a possibility that in some cases, taking large quantities of dietary Flavonoids (e.g red wine, dark chocolate etc) could drive the formation of more aggressive cancers. This is definitely an area that needs a lot more research, and as always make sure that you fully discuss any dietary and supplements with your oncologist.
This is what happens when a ‘fairly normal’ cancer cell is treated with low doses of a Cdk1 inhibitor.
Here is a picture of a polyploid cancer cell, which was produced by partially inhibiting Cdk1.
Aside Posted on Updated on
After some deep thought and consultation with my lab, I have decided to change the lab name from the Mitotic Control lab to the more flexible and public friendly “Cell Division” lab. We feel this name is much simpler to understand, especially for those that are not specialist in the field. It also provides more flexibility for our future research goals, which may take us beyond the control mechanisms that govern mitosis.
All the best
Head of the Cell Division Lab
A Big congratulations to Rachael from our lab who just got her first, 1st Author publication accepted into BJC. A lot of hard work and persistence, and very well deserved. Will post a link to the article once its available online.
I was lucky enough to attend the 3rd Young Garvan Forum for 2013last night on “How close are we to finding the cure for cancer?”.
There were 4 great talks from including 2 from Dr Marina Pajic and Dr Paul Timpson who are fellow researchers here at the Garvan.
The standout talk was by Mr Ben Bravery, who is a young adult Colorectal Cancer Survivor. He has an excellent blog about his personal fight with cancer, which is an excellent read and resource for other cancer patients.