I am very excited to announce our new review paper which is out now in Front Cell Dev Biol [Link]. This is also the first paper from Dr Kamila Marzec who recently joined the lab. Great work! MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It […]Read More New Publication: The Oncogenic Functions of MASTL Kinase
More great news, we have another co-author publication in the outstanding journal Gut. This fabulous work was pioneered by the very talented Dr Marina Pajic and her group at the Garvan Institute. We were very honoured to be involved in such amazing work. The title of the publication is “Tailored first-line and second-line CDK4-targeting treatment […]Read More New Co-Author Publication in Gut: CDK4 inhibitors for treatment of Pancreatic Cancer
Great news, we have published a co-authored paper entitled ‘Ensa controls S-phase length by modulating Treslin levels’ in the prestigious journal ‘Nature Communications’. This work was started back in 2011 when I was a Post-Doc in the laboratory of Anna Castro in France. It’s exciting to see those inital discoveries transition into the finished paper. The […]Read More New Co-Author Publication! Ensa controls S-phase length by modulating Treslin levels.
We are incredibly excited to announce that our SnapShot is out today in Cell! This snapshot of mitosis collates hundreds of phosphorylation events and directly links them with their regulatory kinases and counterbalancing phosphatases, in both time and space, in a highly innovative ‘circtanglar’ cell layout. More importantly, the static PDF version is accompanied by an […]Read More New Publication in Cell! The Phosphoregulation of Mitosis
8th Garvan Signalling Symposium Date: Monday 31st of October and Tuesday 1st of November 2016 Venue: The Garvan Institute of Medical Research, Sydney Registration – Abstract submission to 15th of September 2016 The Garvan International Signalling Symposium is a premier meeting focused on the mechanisms of signal transduction. It began as a small meeting organised by […]Read More 8th Garvan Signalling Symposium – Registration Now Open !!!
Great News, our review on how phosphatase specificity is controlled during mitosis has been re-published in BioEssays and is now Online! This review was originally published in Inside the Cell, which unfortunately has shut down. But the good news is that it is still Open Access, so that means its free for everyone to read! And […]Read More BioEssays Review on Mitotic Phosphatase Specificity now Online
A defining feature in over 2/3rds of all solid tumours is the continual loss and gain of whole are small parts of chromosomes. This instability, or CIN for short, strongly implicated in tumour initiation, progression, chemoresistance and poor prognosis. CIN is created through failures during mitosis, whereby whole or parts of a chromosome are segregated […]Read More Switching off Cancers Diversity
Great news, we have a new Mini-Review published in Frontiers Oncology entitled “Clinical Overview of MDM2/X-Targeted Therapies“, which is apart of the Research Topic Human tumor-derived p53 mutants: a growing family of oncoproteins Here is a little snippet from the Abstract to wet your appetite! MDM2 and MDMX are the primary negative regulators of p53, which under […]Read More New Publication: Clinical Overview of MDM2/X-Targeted Therapies
Great News, we have a new review article that has just been published online today in Inside the Cell! Its Open Access, so that means its free for everyone to read! During mitotic exit, phosphatases reverse thousands of phosphorylation events in a specific temporal order to ensure that cell division occurs correctly. This review explores how […]Read More New Review Article Published!! “Mechanisms Regulating Phosphatase Specificity During Mitotic Exit”
Great news we are currently looking for a new honours student for 2016. The title of the project is “Developing novel biosensors to monitor DNA damage in cancer cells”. Its a very exciting new project incorporating cutting edge microscopy and fluorescent biosensors. If you think you have what it takes and are interested please feel […]Read More Position available: 2016 Honours Student Project in our Lab