We are incredibly excited to announce that our SnapShot is out today in Cell! This snapshot of mitosis collates hundreds of phosphorylation events and directly links them with their regulatory kinases and counterbalancing phosphatases, in both time and space, in a highly innovative ‘circtanglar’ cell layout. More importantly, the static PDF version is accompanied by an […]Read More New Publication in Cell! The Phosphoregulation of Mitosis
Great News, our review on how phosphatase specificity is controlled during mitosis has been re-published in BioEssays and is now Online! This review was originally published in Inside the Cell, which unfortunately has shut down. But the good news is that it is still Open Access, so that means its free for everyone to read! And […]Read More BioEssays Review on Mitotic Phosphatase Specificity now Online
A defining feature in over 2/3rds of all solid tumours is the continual loss and gain of whole are small parts of chromosomes. This instability, or CIN for short, strongly implicated in tumour initiation, progression, chemoresistance and poor prognosis. CIN is created through failures during mitosis, whereby whole or parts of a chromosome are segregated […]Read More Switching off Cancers Diversity
A recent high profile publication in Science Translational Medicine proposed that antioxidants might increase the rate of metastasis in mice models of melanoma. NAC and the soluble vitamin E analog Trolox markedly increased the migration and invasive properties of human malignant melanoma cells but did not affect their proliferation. Both antioxidants increased the ratio between […]Read More AntiOxidants and Cancer: A complicated story
Great News, we have a new review article that has just been published online today in Inside the Cell! Its Open Access, so that means its free for everyone to read! During mitotic exit, phosphatases reverse thousands of phosphorylation events in a specific temporal order to ensure that cell division occurs correctly. This review explores how […]Read More New Review Article Published!! “Mechanisms Regulating Phosphatase Specificity During Mitotic Exit”
Great news we are currently looking for a new honours student for 2016. The title of the project is “Developing novel biosensors to monitor DNA damage in cancer cells”. Its a very exciting new project incorporating cutting edge microscopy and fluorescent biosensors. If you think you have what it takes and are interested please feel […]Read More Position available: 2016 Honours Student Project in our Lab
Great news, we have another publication. This time its some extra data left over from our large mass spectrometry study we published in August in Molecular & Cellular Proteomics. This latest work we provide additional analysis of our large proteomics dataset and identify motifs that correlated strongly with phosphorylation status for each of the major mitotic kinases. These motifs […]Read More New Paper Published! More data on the global phosphorylation changes during early mitotic exit
Great news our latest publication “Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs” has been accepted by the top Proteomics Journal Molecular & Cellular Proteomics. You can currently download the unformatted version for free here [link] And here is an still image from the paper showing live HeLa […]Read More Our Latest Publication Accepted and Now Online!
Great news, we recently published a collaborative paper in the journal Cell Division with the Lab of Dr Liz Caldon here at the Garvan. The title of the paper is “Cyclin E2 is the predominant E-cyclin associated with NPAT in breast cancer cells”, and you can find it online here It also marked the […]Read More Congratulation to Sam our PhD student on his 1st Author Publication!
Big congratulations to our PhD student Sam Rogers, who took out best poster at last weeks inaugural EMBL Australian PhD Symposium, held at UNSW. An amazing achievement considering that he is still only in his first year. Well done Sam !Read More Sam Rogers – Best Poster winner @ EMBL Australia Student Symposium 2014