A defining feature in over 2/3rds of all solid tumours is the continual loss and gain of whole are small parts of chromosomes. This instability, or CIN for short, strongly implicated in tumour initiation, progression, chemoresistance and poor prognosis. CIN is created through failures during mitosis, whereby whole or parts of a chromosome are segregated […]Read More Switching off Cancers Diversity
Here is a recent talk I gave to some members of the public at the Garvan Institute of Medical Research. It is a very general and simple over-view of explaining 1) how cells in your body proliferate, 2) how this goes wrong in cancer, 3) the challenges we are facing in treating and killing cancer, and […]Read More Public Talk “Killing Cancer One Cell at a Time ” now on YouTube
There has been a bit of press lately suggesting that Antioxidants might actually be bad for cancer… not good as they are commonly promoted in the media. IFLS has put together a great article on some of the reasons why antioxidants might not be such a great thing [Link]. In addition, we recently wrote a […]Read More Anti-Oxaidants and Cancer…A complicated story!
Great news, our latest review article “Stressing Mitosis to Death” has been accepted for publication by Frontiers in Oncology. You can access the provisional pre-press version here. The review is about how common stresses affect mitosis, and the impact these stresses can have on the blockbuster mitotic chemotherapy drug Taxol (paclitaxel) Finally here is one of […]Read More Our Latest Review Article “Stressing Mitosis to Death” is now online !
Some more good news to coincide with today’s official release of our manuscript, one of our images has been chosen to be the feature image on the front cover. It’s a great honour, one that I am very proud of, and is the first time I have ever had a front cover ! You can […]Read More Were the front cover feature image on this months issue of Cell Cycle !
You can now download the final PDF version of our latest work here: https://www.landesbioscience.com/journals/cc/article/28401/ The great news is that its also open access so anyone and everyone can view and download it. Enjoy !Read More Our Cell Cycle Paper is now Live and Open Access
Here is one of the images that we took using a Leica SP8 confocal microscope this week in the lab. It is a 3D image of a HeLa cell that has completely stuffed up mitosis (undergone mitotic catastrophe). It has separated whole chromosomes randomly into 2 daughter cells instead of separating the two identical chromatids in […]Read More Cell Image of the Week – Mitotic Catastrophe
Our favourite protein in the lab is Greatwall kinase. It was first discovered in 2004 to be critical for cell division in fruit flies (1,2) . The trail then went cold for a few years as to its exact function, but in 2009, while I was working as a post-doc in France, I was fortunate […]Read More A brief Intro to Greatwall Kinase…The King of Mitosis
For a bit of fun way for us to show our research to the public, we have opened up a Redbubble store with some great Mitotic themed items inspired by the research that we do. 100% of any profits made will be used to directly fund further research (and or coffee) to keep us awake so […]Read More Mitotic Control Lab now has a Redbubble Store
The Garvan recently took possession of a fantastic new Leica SP8 confocal microscope, which we have been lucky enough to have play with. Here are the results from our first go with the microscope. Very impressive, and we are yet to push the system to its fully potential. The massive increase in resolution and quality […]Read More New Mitotic Movies