Its been a big month for publications, with 2 new co-author papers coming out. The first entitled “Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling” was published in the prestigious Journal of Clinical Investigation (JCI). [Link] Ligand-dependent activation of Hedgehog (Hh) signaling in cancer occurs without mutations in canonical pathway genes. Consequently, the genetic […]Read More New Co-author publications in Cancers and JCI
I am very excited to announce our new review paper which is out now in Front Cell Dev Biol [Link]. This is also the first paper from Dr Kamila Marzec who recently joined the lab. Great work! MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It […]Read More New Publication: The Oncogenic Functions of MASTL Kinase
Great news, we have a new co-author publication out in the journal Oncogene! The work was lead by Professor Neil Watkins, and is titled “The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53”. You can access the full article here [Link] ABSTRACT: Hypermethylated-in-Cancer 1 (Hic1) is a tumor suppressor gene frequently inactivated by epigenetic […]Read More New Co-author Publication: Hic1 maintains chromosomal stability independent of p53
Great news, we have published a co-authored paper entitled ‘Ensa controls S-phase length by modulating Treslin levels’ in the prestigious journal ‘Nature Communications’. This work was started back in 2011 when I was a Post-Doc in the laboratory of Anna Castro in France. It’s exciting to see those inital discoveries transition into the finished paper. The […]Read More New Co-Author Publication! Ensa controls S-phase length by modulating Treslin levels.
Great news we are currently looking for a new honours student for 2016. The title of the project is “Developing novel biosensors to monitor DNA damage in cancer cells”. Its a very exciting new project incorporating cutting edge microscopy and fluorescent biosensors. If you think you have what it takes and are interested please feel […]Read More Position available: 2016 Honours Student Project in our Lab
Here is a slide that I made and often use at the beginning of my talks to briefly explain what mitosis is. The images are taken from a live cell that we have labelled with fluorescent probes to highlight the DNA (red) and microtubules (green). Enjoy !Read More A brief introduction to Mitosis
Here is a HeLa cell in the first stages of mitosis (prophase) just as it has begun to condensing its DNA into chromosomes. At this point it looks strikingly similar to the folds of a human brain. The image has been put through a few photoshop filters to give this stunning final image.Read More Cell Brains – Image of the Week
There is an excellent Conference coming up in the beautiful southern French city of Montpellier. There is an amazing line up of world class speakers, so book the dates in your calendar for 2-5th April 2013 ! Closing date for abstracts is Feb 24th 2013, with registration costing from €200-300 for students and academics.Read More 3rd Cell Cycle and Cancer Conference – April 2013 Montpellier France !
I am pleased to announce that the latest publication for the lab is now available online at PLoS ONE [Link][PDF]. Below are some additional videos of the Chromotek HeLa cell line [link] undergoing cell division, with the Imaris Dot quantification overlaid, along with a instructional video on how to perform the dot quantification analysis using […]Read More New Paper Published : Quantitative Live Imaging of Endogenous DNA Replication in Mammalian Cells