More great news, we have another co-author publication in the outstanding journal Gut. This fabulous work was pioneered by the very talented Dr Marina Pajic and her group at the Garvan Institute. We were very honoured to be involved in such amazing work. The title of the publication is “Tailored first-line and second-line CDK4-targeting treatment […]Read More New Co-Author Publication in Gut: CDK4 inhibitors for treatment of Pancreatic Cancer
We are incredibly excited to announce that our SnapShot is out today in Cell! This snapshot of mitosis collates hundreds of phosphorylation events and directly links them with their regulatory kinases and counterbalancing phosphatases, in both time and space, in a highly innovative ‘circtanglar’ cell layout. More importantly, the static PDF version is accompanied by an […]Read More New Publication in Cell! The Phosphoregulation of Mitosis
8th Garvan Signalling Symposium Date: Monday 31st of October and Tuesday 1st of November 2016 Venue: The Garvan Institute of Medical Research, Sydney Registration – Abstract submission to 15th of September 2016 The Garvan International Signalling Symposium is a premier meeting focused on the mechanisms of signal transduction. It began as a small meeting organised by […]Read More 8th Garvan Signalling Symposium – Registration Now Open !!!
A defining feature in over 2/3rds of all solid tumours is the continual loss and gain of whole are small parts of chromosomes. This instability, or CIN for short, strongly implicated in tumour initiation, progression, chemoresistance and poor prognosis. CIN is created through failures during mitosis, whereby whole or parts of a chromosome are segregated […]Read More Switching off Cancers Diversity
Great news, we have a new Mini-Review published in Frontiers Oncology entitled “Clinical Overview of MDM2/X-Targeted Therapies“, which is apart of the Research Topic Human tumor-derived p53 mutants: a growing family of oncoproteins Here is a little snippet from the Abstract to wet your appetite! MDM2 and MDMX are the primary negative regulators of p53, which under […]Read More New Publication: Clinical Overview of MDM2/X-Targeted Therapies
A recent high profile publication in Science Translational Medicine proposed that antioxidants might increase the rate of metastasis in mice models of melanoma. NAC and the soluble vitamin E analog Trolox markedly increased the migration and invasive properties of human malignant melanoma cells but did not affect their proliferation. Both antioxidants increased the ratio between […]Read More AntiOxidants and Cancer: A complicated story
Great news, we have another publication. This time its some extra data left over from our large mass spectrometry study we published in August in Molecular & Cellular Proteomics. This latest work we provide additional analysis of our large proteomics dataset and identify motifs that correlated strongly with phosphorylation status for each of the major mitotic kinases. These motifs […]Read More New Paper Published! More data on the global phosphorylation changes during early mitotic exit
Great news our latest publication “Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs” has been accepted by the top Proteomics Journal Molecular & Cellular Proteomics. You can currently download the unformatted version for free here [link] And here is an still image from the paper showing live HeLa […]Read More Our Latest Publication Accepted and Now Online!
Great news, we recently published a collaborative paper in the journal Cell Division with the Lab of Dr Liz Caldon here at the Garvan. The title of the paper is “Cyclin E2 is the predominant E-cyclin associated with NPAT in breast cancer cells”, and you can find it online here It also marked the […]Read More Congratulation to Sam our PhD student on his 1st Author Publication!
Big congratulations to our PhD student Sam Rogers, who took out best poster at last weeks inaugural EMBL Australian PhD Symposium, held at UNSW. An amazing achievement considering that he is still only in his first year. Well done Sam !Read More Sam Rogers – Best Poster winner @ EMBL Australia Student Symposium 2014