We are very excited to announce the publishing of “A Compendium to the Phosphoregulation of Mitosis” on the open access repository Zenodo. This compendium accompanies the 2017 publication in Cell and the interactive website. In the compendium, we have compiled all the text from the 88 popups in the online interactive visualization, with the aim […]Read More A Compendium to the Phosphoregulation of Mitosis
I am very excited to announce our new review paper which is out now in Front Cell Dev Biol [Link]. This is also the first paper from Dr Kamila Marzec who recently joined the lab. Great work! MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It […]Read More New Publication: The Oncogenic Functions of MASTL Kinase
Great News, our review on how phosphatase specificity is controlled during mitosis has been re-published in BioEssays and is now Online! This review was originally published in Inside the Cell, which unfortunately has shut down. But the good news is that it is still Open Access, so that means its free for everyone to read! And […]Read More BioEssays Review on Mitotic Phosphatase Specificity now Online
A defining feature in over 2/3rds of all solid tumours is the continual loss and gain of whole are small parts of chromosomes. This instability, or CIN for short, strongly implicated in tumour initiation, progression, chemoresistance and poor prognosis. CIN is created through failures during mitosis, whereby whole or parts of a chromosome are segregated […]Read More Switching off Cancers Diversity
Great News, we have a new review article that has just been published online today in Inside the Cell! Its Open Access, so that means its free for everyone to read! During mitotic exit, phosphatases reverse thousands of phosphorylation events in a specific temporal order to ensure that cell division occurs correctly. This review explores how […]Read More New Review Article Published!! “Mechanisms Regulating Phosphatase Specificity During Mitotic Exit”
Great news, we have another publication. This time its some extra data left over from our large mass spectrometry study we published in August in Molecular & Cellular Proteomics. This latest work we provide additional analysis of our large proteomics dataset and identify motifs that correlated strongly with phosphorylation status for each of the major mitotic kinases. These motifs […]Read More New Paper Published! More data on the global phosphorylation changes during early mitotic exit
Great news our latest publication “Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs” has been accepted by the top Proteomics Journal Molecular & Cellular Proteomics. You can currently download the unformatted version for free here [link] And here is an still image from the paper showing live HeLa […]Read More Our Latest Publication Accepted and Now Online!
Some more good news to coincide with today’s official release of our manuscript, one of our images has been chosen to be the feature image on the front cover. It’s a great honour, one that I am very proud of, and is the first time I have ever had a front cover ! You can […]Read More Were the front cover feature image on this months issue of Cell Cycle !
You can now download the final PDF version of our latest work here: https://www.landesbioscience.com/journals/cc/article/28401/ The great news is that its also open access so anyone and everyone can view and download it. Enjoy !Read More Our Cell Cycle Paper is now Live and Open Access
Our favourite protein in the lab is Greatwall kinase. It was first discovered in 2004 to be critical for cell division in fruit flies (1,2) . The trail then went cold for a few years as to its exact function, but in 2009, while I was working as a post-doc in France, I was fortunate […]Read More A brief Intro to Greatwall Kinase…The King of Mitosis