New Publication in Cell! The Phosphoregulation of Mitosis

We are incredibly excited to announce that our SnapShot is out today in Cell! This snapshot of mitosis collates hundreds of phosphorylation events and directly links them with their regulatory kinases and counterbalancing phosphatases, in both time and space, in a highly innovative ‘circtanglar’ cell layout. More importantly, the static PDF version is accompanied by an […]

Read More New Publication in Cell! The Phosphoregulation of Mitosis

Switching off Cancers Diversity

A defining feature in over 2/3rds of all solid tumours is the continual loss and gain of whole are small parts of chromosomes. This instability, or CIN for short, strongly implicated in tumour initiation, progression, chemoresistance and poor prognosis. CIN is created through failures during mitosis, whereby whole or parts of a chromosome are segregated […]

Read More Switching off Cancers Diversity

New Review Article Published!! “Mechanisms Regulating Phosphatase Specificity During Mitotic Exit”

Great News, we have a new review article that has just been published online today in Inside the Cell! Its Open Access, so that means its free for everyone to read! During mitotic exit, phosphatases reverse thousands of phosphorylation events in a specific temporal order to ensure that cell division occurs correctly. This review explores how […]

Read More New Review Article Published!! “Mechanisms Regulating Phosphatase Specificity During Mitotic Exit”

New Paper Published! More data on the global phosphorylation changes during early mitotic exit

Great news, we have another publication. This time its some extra data left over from our large mass spectrometry study we published in August in Molecular & Cellular Proteomics. This latest work we provide additional analysis of our large proteomics dataset and identify motifs that correlated strongly with phosphorylation status for each of the major mitotic kinases. These motifs […]

Read More New Paper Published! More data on the global phosphorylation changes during early mitotic exit